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My current research interest involves the role that phytochemicals play in reducing proliferation of canine osteosarcoma (bone cancer) cells. Much recent research has focused on the use of plant chemicals as chemotherapeutics, both because of availability and of their less toxic effect, overall, to the animal under treatment. Students in my laboratory use a variety of techniques to investigate the pathways involved in the phytochemical effect, including: animal tissue culture, cell proliferation assays, mRNA level analysis using reverse transcription and quantitative PCR, flow cytometery to measure oxidative damage and apoptosis, and epigenetic analysis of both histones and DNA. The majority of projects involve the investigation of both the antioxidant and pro-oxidant effects of phytochemicals on cells and the major pathways investigated are those involved with oxidative stress response, cell cycle regulation, and prostaglandin synthesis.