Title: Assistant Professor of Biology and Neuroscience
Primary Department: Biology
Other Programs: Neuroscience, Community and Justice Studies
Degrees: B.S. Elizabethtown College; Ph.D. Vanderbilt University
Phone: (814) 332-3021Office Location: Steffee Hall B200
Website: Click here
My research areas are the fields of vision and metabolism. Located at the back of the eye, the retina is a highly differentiated tissue that consumes glucose exclusively and requires vitamin A for much of its activity and development. Many proteins are needed to transduce a signal from the photoreceptor and to recycle vitamin A in this tissue. Mutations in many of these vitamin A-related proteins result in retinal degeneration and/or impaired visual function. We hypothesize that one of these proteins, interphotoreceptor retinoid-binding protein, also has a developmental role in the retina such that apoptosis occurs in the absence of this protein. My research is focused on understanding the other genes involved in this early retinal degeneration using quantitative PCR to study gene expression in mouse retinal tissue.
I am also interested inlipofuscin, diabetes, sepsis, and the new area of metabolomics.
My projects will typically use mice and may involve in vivo experiments, collection of tissues, enzyme assays, and gene expression analyses (qPCR).